Alaska Community Reaches Out to PCSS

Meeting between healthcare professionals

One small, rural Alaskan community known for its famous fishing along the glacial-fed Kenai River, like so many other regions of the country has been struggling with a growing heroin crisis that has left clinicians scrambling for solutions. Central Peninsula General Hospital is a 40-bed facility located south of Anchorage that has seen a marked […]

Injectable naltrexone, oral naltrexone, and buprenorphine utilization and discontinuation among individuals treated for opioid use disorder in a United States commercially insured population

Pharmacist's hands taking medicines from shelf

We investigated prescribing patterns for five opioid use disorder (OUD) medications: 1) injectable naltrexone, 2) oral naltrexone, 3) sublingual or oromucosal buprenorphine/naloxone, 4) sublingual buprenorphine, and 5) transdermal buprenorphine in a nationally representative claims-based database (Truven Health MarketScan®) of commercially insured individuals in the United States. We calculated the prevalence of OUD in the database […]

An Evidence-Based Recommendation to Increase the Dosing Frequency of Buprenorphine During Pregnancy

Close up Stethoscope. Doctor working in hospital

Dose-adjusted plasma concentrations of buprenorphine are significantly decreased during pregnancy compared to the non-pregnant state. This observation suggests that pregnant women may need a higher dose of buprenorphine than non-pregnant individuals in order to maintain similar drug exposure (plasma concentrations over time after a dose). The current dosing recommendations for buprenorphine during pregnancy address the […]